SnapShot: Histone Readers

SnapShot: Histone Readers

SnapShot: Histone Modifications

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SnapShot: Histone-Modifying Enzymes

SnapShot: Histone Lysine Methylase Complexes

Writers and readers of histone acetylation: structure, mechanism, and inhibition.

Histone acetylation marks are written by histone acetyltransferases (HATs) and read by bromodomains (BrDs), and less commonly by other protein modules. These proteins regulate many transcription-mediated biological processes, and their aberrant activities are correlated with several human diseases. Consequently, small molecule HAT and BrD inhibitors with therapeutic potential have been develope...